Supramolecular Organization of the α121-α565 Collagen IV Network

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Supramolecular organization of the α121-α565 collagen IV network.

Collagen IV is a family of 6 chains (α1-α6), that form triple-helical protomers that assemble into supramolecular networks. Two distinct networks with chain compositions of α121 and α345 have been established. These oligomerize into separate α121 and α345 networks by a homotypic interaction through their trimeric noncollagenous (NC1) domains, forming α121 and α345 NC1 hexamers, respectively. Th...

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ژورنال

عنوان ژورنال: Journal of Biological Chemistry

سال: 2014

ISSN: 0021-9258

DOI: 10.1074/jbc.m114.571844